Article

A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites

2022-09-30

Abstract excerpt

Malaria parasites avoid immune clearance through their ability to systematically alter antigens exposed on the surface of infected red blood cells. This is accomplished by tightly regulated transcriptional control of individual members of a large, multicopy gene family called var and is the key to both the virulence and chronic nature of malaria infections. Expression of var genes is mutually exclusive and contr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa23a349-c457-5146-a39a-50aae05a47a5
DOI: 10.1101/2022.09.29.510131

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A coordinated transcriptional switching network mediates antigenic variation of human malaria parasitesDOI 10.1101/2022.09.29.510131Read

A coordinated transcriptional switching network mediates antigenic variation of human malaria parasitesSemantic proximity Read

The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasitesSemantic proximity Read

Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunitySemantic proximity Read

A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparumSemantic proximity Read

Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.Semantic proximity Read

Epigenetic memory at malaria virulence genesSemantic proximity Read

Antigenic variation and the generation of diversity in malaria parasites.Semantic proximity Read

Variant antigen gene expression in malariaSemantic proximity Read

Variant Gene Expression and Antigenic Variation by Malaria ParasitesSemantic proximity Read

Silence, activate, poise and switch! Mechanisms of antigenic variation in P lasmodium falciparumSemantic proximity Read

Default Pathway of var2csa switching and translational repression in Plasmodium falciparum.Semantic proximity Read

Variable switching rates of malaria virulence genes are associated with chromosomal position.Semantic proximity Read