Article

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase Influenced the Age Onset of Parkinson’s Disease

2021-06-04

Abstract excerpt

<h4>Aims: </h4> Earlier studies reported alterations of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism in Parkinson’s disease (PD). The first rate-limiting enzymes indoleamine 2,3- dioxygenase (IDO) and tryptophan dioxygenase were observed upregulated, resulting elevated KYN/TRP ratios in the serum and cerebrospinal fluid samples of patients with PD. An increasing number of single nucleotide pol...

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Literature Corpus work: 37ed4240-5cd1-5659-b881-a129e0fb1af3
DOI: 10.20944/preprints202010.0172.v2

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