Article

Dopamine pathway and Parkinson’s risk variants are associated with levodopa-induced dyskinesia

2023-08-30

Abstract excerpt

<h4>Background</h4> Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson’s disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes implicated in PD, including GBA1 and LRRK2 . <h4>Objectives</h4> To investigate the effects of genetic variants on risk...

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Literature Corpus work: 4e38c971-250a-5bc0-bbdb-8f77f0101997
DOI: 10.1101/2023.08.28.23294610

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