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Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease.

Frontiers in bioscience (Landmark edition) - 27 Sept 2022

Török Nóra, Maszlag-Török Rita, Molnár Kinga, Szolnoki Zoltán, Somogyvári Ferenc, Boda Krisztina, Tanaka Masaru, Klivényi Péter, Vécsei László

Abstract excerpt

BACKGROUND: Earlier studies reported alterations of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism in Parkinson's disease (PD). The first rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase were observed upregulated, resulting elevated KYN/TRP ratios in the serum and cerebrospinal fluid samples of patients with PD. More and more single nucleotide polymorphisms (SNPs)...

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PMID: 36224022
DOI: 10.31083/j.fbl2709265

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