Article

Human AUTS2 regulates neurodevelopmental pathways via dual DNA/RNA binding

2025-10-08

Abstract excerpt

The AUTS2 gene is implicated in neurodevelopmental and psychiatric disorders, with patient mutations leading to intellectual disability, microcephaly, and autistic behavior. While AUTS2’s chromatin-and RNA-related functions are recognized, its direct binding to RNA in human neural progenitors has not been previously demonstrated. Here, we used ChIP-seq and eCLIP-seq in human neural progenitor cells (NPCs) to map...

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Literature Corpus work: 37dba581-8315-57b4-aff8-3bc3ae1aa3ea
DOI: 10.1101/2025.10.07.681056

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