Article

Age-related loss of the Y chromosome is associated with sex hormone binding globulin and selected drivers of clonal hematopoiesis

2022-09-09

Abstract excerpt

Mosaic loss of the Y-chromosome (LOY) is the most common somatic alteration in men. We aimed to assess the relationship between LOY and serum biomarkers in UK Biobank and explore the interaction with constitutional and somatic genetics. LOY was strongly associated with levels of sex hormone binding globulin (SHBG, β=0.12, P FDR = P = 7.44×10 −36 , adjusted for age, age squared, gender, smoking status, smoking inte...

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Literature Corpus work: 37daa5b9-b8f2-5bd2-82c0-d680a73e17fc
DOI: 10.1101/2022.09.05.22279615

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