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<i>CHRFAM7A</i> overexpression in human iPSC-derived Interneurons dysregulates α7- nAChR surface expression and alters response to oligomeric β-amyloid peptide

2024-06-05

Abstract excerpt

The α7 neuronal nicotinic receptor (α7-nAChR) gene, CHRNA7 , is widely expressed within the brain and at the periphery. It plays various important roles in cognition and immune functions. Decreased expression of α7-nAChR has been associated with Alzheimer’s disease (AD) triggered by the accumulation of the 42-amino acid beta-amyloid peptide (Aβ 1-42 ). The interactions of this peptide with α7-nAChR may represent...

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Literature Corpus work
37d8babb-c9b9-5f4a-8d42-6630ffe5203b
DOI
10.1101/2024.06.04.597325
Open publication

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<i>CHRFAM7A</i> overexpression in human iPSC-derived Interneurons dysregulates α7- nAChR surface expression and alters response to oligomeric β-amyloid peptideDOI 10.1101/2024.06.04.597325
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