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Deletion induced splicing in <i>RIC3</i> drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes

2022-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Nicotinic acetylcholine receptor (nAChR) dysregulation in astrocytes is reported in neurodegenerative disorders. Modulation of nAChRs through agonists confers protection to astrocytes from stress but regulation of chaperones is unclear. Resistance to inhibitors of cholinesterase 3 ( RIC3 ) is a potential chaperone of nAChRs but poorly studied in humans. We characterized RIC3 in astrocytes deri...

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Literature Corpus work
c71e60b3-05fa-5671-b27f-aa65f59cd14e
DOI
10.1101/2022.07.18.500445
Open publication

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Deletion induced splicing in <i>RIC3</i> drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytesDOI 10.1101/2022.07.18.500445
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