Article

Modeling Dry AMD in Primary Retinal Pigment Epithelium: Time-Dependent Hydroxyapatite Deposition and Disease-Relevant Transcriptomic Changes

2026-05-29

Abstract excerpt

<title>Abstract</title> <p> Objective Age-related macular degeneration (AMD) is the leading cause of visual impairment in older adults. Despite extensive studies on AMD, the mechanism of drusen formation remains unknown, limiting the development of therapeutic approaches. Therefore, our goal was to establish a reproducible primary porcine retinal pigment epithelium (RPE) model featuring dry AMD and characterize...

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Literature Corpus work: 37b4048a-217a-544a-983b-9c3e970a82f0
DOI: 10.21203/rs.3.rs-9719090/v1

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