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The early evolution of chronic clonal lymphocytosis

2026-01-29

Abstract excerpt

<title>Abstract</title> <p> Mature B-cell neoplasms often present with chronic clonal lymphocytosis, yet their earliest evolutionary stages and precise origins remain unclear. Using single-cell RNA and paired BCR sequencing with targeted DNA analysis across B-cell differentiation, we identified distinct pathological B-cell states—memory, aged, CLL, and aged-HCL—that only partially aligned with clinical diagnoses...

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Literature Corpus work
ddef7a2b-b6db-50d0-84a1-e699bee76b6a
DOI
10.21203/rs.3.rs-8160900/v1
Open publication

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