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Article

Early Parkinson's disease symptoms in -synuclein transgenic monkeys

30 Dec 2014

Abstract excerpt

Parkinson's disease (PD) is an age-dependent neurodegenerative disease that can be caused by genetic mutations in α-synuclein (α-syn) or duplication of wild-type α-syn; PD is characterized by the deposition of α-syn aggregates, indicating a gain of toxicity from accumulation of α-syn. Although the major neuropathologic feature of PD is the degeneration of dopaminergic (DA) neurons in the substantia nigra,...

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PMID: 25552648
DOI: 10.1093/hmg/ddu748

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