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Article

Cryo-EM of prion strains from the same genotype of host identifies conformational determinants

2022-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic structures of prions from two host species with different PrP sequences have been determined but comparisons of distinct prion strains of the same amino acid sequence a...

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Literature Corpus work
37704f37-75d6-5693-a942-65c5324e585e
DOI
10.1101/2022.09.19.508587
Open publication

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Cryo-EM of prion strains from the same genotype of host identifies conformational determinantsDOI 10.1101/2022.09.19.508587
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