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Article

Cryo-EM of prion strains from the same genotype of host identifies conformational determinants.

PLoS pathogens - 1 Nov 2022

Hoyt Forrest, Alam Parvez, Artikis Efrosini, Schwartz Cindi L, Hughson Andrew G, Race Brent, Baune Chase, Raymond Gregory J, Baron Gerald S, Kraus Allison, Caughey Byron

Abstract excerpt

Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic structures of prions from two host species with different PrP sequences have been determined but comparisons of distinct prion strains of the same amino acid sequence are needed to...

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Identifiers

PMID: 36342968
DOI: 10.1371/journal.ppat.1010947
PMCID: PMC9671466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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