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Article

Molecular foundations of prion strain diversity.

Current opinion in neurobiology - 1 Feb 2022

Carta Manfredi, Aguzzi Adriano

Abstract excerpt

Despite being caused by a single protein, prion diseases are strikingly heterogenous. Individual prion variants, known as strains, possess distinct biochemical properties, form aggregates with characteristic morphologies and preferentially seed certain brain regions, causing markedly different disease phenotypes. Strain diversity is determined by protein structure, post-translational modifications and the...

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Identifiers

PMID: 34416480
DOI: 10.1016/j.conb.2021.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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