Article

Structural Basis of Glycoform Selectivity in Prion Strains

2025-11-05

Abstract excerpt

Prion diseases originate from the pathological misfolding of the cellular sialoglycoprotein prion protein (PrPC), universally found across mammalian species, into an aberrant conformation termed PrPSc, which exhibits high aggregation propensity and neurotoxicity. Distinct conformations of the misfolded and aggregated PrPSc, termed prion strains, can cause different disease phenotypes and transmission characteristi...

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Literature Corpus work: 83ee1966-68d6-517c-844c-691ca97afa34
DOI: 10.1101/2025.11.04.686259

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