Article
Mouse models of myeloproliferative neoplasms: JAK of all grades.
Disease models & mechanisms - 1 May 2011
Li Juan, Kent David G, Chen Edwin, Green Anthony R
Abstract excerpt
In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs). Since this discovery, much effort has been dedicated to understanding the molecular consequences of the JAK2V617F mutation in the haematopoietic system. Three waves of mouse models have been produced recently (bone marrow...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.