Article

CRISPR/Cas9 screenings reveal the role of STX1A and CDK1 in Cathepsin G entering and killing colorectal cancer cells

2025-09-26

Abstract excerpt

Neutrophils are the major populations of white blood cells and have been reported to facilitate cancer metastasis. Meanwhile, emerging evidence has recently suggested the anti-cancer role of neutrophils. Our previous study revealed that CB-839 and 5-FU-treated colorectal cancer (CRC) tumors recruited neutrophils and induced neutrophil extracellular traps (NETs). Cathepsin G (CTSG), which is released during NET for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3760dbea-ada1-514d-a83f-1f64f25c58e2
DOI: 10.1101/2025.09.24.678097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 screenings reveal the role of STX1A and CDK1 in Cathepsin G entering and killing colorectal cancer cellsDOI 10.1101/2025.09.24.678097Read

Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and MetastasisSemantic proximity Read

Neutrophil extracellular traps in cancerSemantic proximity Read

The emerging role of neutrophil extracellular traps in cancer: from lab to wardSemantic proximity Read

Regulation of neutrophil extracellular traps in cancerSemantic proximity Read

Neutrophils in Cancer and Potential Therapeutic Strategies using Neutrophil-derived ExosomesSemantic proximity Read

NETosis as an oncologic therapeutic target: a mini reviewSemantic proximity Read

Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancerSemantic proximity Read

Multi-omics analysis reveals that neutrophil extracellular traps related gene TIMP1 promotes CRC progression and influences ferroptosisSemantic proximity Read

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafishSemantic proximity Read

Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1Semantic proximity Read

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.Semantic proximity Read

Interferon Gamma Induces Higher Neutrophil Extracellular Traps Leading to Tumor-Killing Activity in Microsatellite Stable Colorectal CancerSemantic proximity Read