Article
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.
Nature communications - 21 Mar 2016
Guglietta Silvia, Chiavelli Andrea, Zagato Elena, Krieg Carsten, Gandini Sara, Ravenda Paola Simona, Bazolli Barbara, Lu Bao, Penna Giuseppe, Rescigno Maria
Abstract excerpt
Excessive activation of blood coagulation and neutrophil accumulation have been described in several human cancers. However, whether hypercoagulation and neutrophilia are linked and involved in cancer development is currently unknown. Here we show that spontaneous intestinal tumorigenesis correlates with the accumulation of low-density neutrophils with a pro-tumorigenic N2 phenotype and unprompted neutrophil...
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