Article

Tumor-Intrinsic Epigenetic Programs Associated with Nodal Burden and Metastatic Risk in ER+/HER2- Breast Cancer

2026-06-26

Abstract excerpt

De-escalation of axillary surgery in breast cancer (BC) reduces surgical morbidity but limits pathological assessment of nodal burden, a key determinant of prognosis and adjuvant therapy in estrogen receptor-positive (ER+)/HER2- BC. Tumor-intrinsic biomarkers that reflect the extent of lymph node disease may help bridge this gap. We performed genome-wide DNA methylation profiling of primary tumors from patients wi...

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Literature Corpus work: 373b0d8f-2c81-5004-90ca-8834ac40ddad
DOI: 10.20944/preprints202606.1925.v1

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