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Article

Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [18F]PI-2620.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 3 Jun 2024

Bischof Gérard N, Brendel Matthias, Barthel Henryk, Theis Hendrik, Barbe Michael, Bartenstein Peter, Claasen Joseph, Danek Adrian, Höglinger Günter, Levin Johannes, Marek Ken, Neumaier Bernd, Palleis Carla, Patt Marianne, Rullmann Michael, Saur Dorothee, Schroeter Matthias L, Seibyl John, Song Mengmeng, Stephens Andrew, Sabri Osama, Drzezga Alexander, van Eimeren Thilo

Abstract excerpt

We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2620) in a group of patients clinically diagnosed with 4-repeat tauopathy, specifically progressive supranuclear palsy or cortical basal syndrome. The study found that SUV...

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Identifiers

PMID: 38575191
DOI: 10.2967/jnumed.123.265930
PMCID: PMC11149601

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