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An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with <sup>18</sup>F-PM-PBB3 (<sup>18</sup>F-APN-1607)

2022-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Positron emission tomography (PET) with 18 F-PM-PBB3 ( 18 F-APN-1607) enables high-contrast detection of tau depositions in various neurodegenerative dementias, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). A simplified method for quantifying the radioligand binding in target regions is to employ the cerebellum as a reference (CB-ref) on the assumption that the...

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Literature Corpus work
d59f97bb-3123-5f77-bf74-3a31de7caa04
DOI
10.1101/2022.02.13.22270135
Open publication

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An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with <sup>18</sup>F-PM-PBB3 (<sup>18</sup>F-APN-1607)DOI 10.1101/2022.02.13.22270135
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