Article

Germline TLR7 Biology and Precision Stratification for TLR7/8 Agonism in Melanoma and Lung Cancer

2026-05-28

Abstract excerpt

<title>Abstract</title> <p>Background Toll-like receptor 7 (TLR7) signaling plays a central role in innate immune activation, dendritic cell priming, and antitumor immunity. Clinical responses to TLR7/8 agonists such as EIK1001 appear heterogeneous, suggesting underlying host immunogenetic determinants of response. Methods We integrated germline genetic, proteomic, transcriptomic, and real-world clinical datase...

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Literature Corpus work: 36ed58d4-6ec6-5d03-85fd-7e1ffc2ec07a
DOI: 10.21203/rs.3.rs-9837932/v1

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