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Article

Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma.

Aging - 8 Nov 2021

Wang Qinghua, Lyu Juncheng, Zhang Wenjing, Shi Fuyan, Ren Yanfeng, Mao Qian, Liu Yujie, Li Yuting, Wang Suzhen

Abstract excerpt

Recent studies have demonstrated the role of Nod-like receptor protein 3 (NLRP3) inflammasome in promoting melanoma progression. Immune checkpoint inhibitors (ICI) treatment dramatically extended the survival outcomes for advanced melanoma patients. Nevertheless, immunologic and immunotherapy implications of NLRP3 mutations in melanoma were obscure. Herein, we utilized publicly genomic data of 750 melanoma...

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Identifiers

PMID: 34747716
DOI: 10.18632/aging.203678
PMCID: PMC8610131

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