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Article

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.

Nature medicine - 1 Dec 2022

Taylor Chelsea A, Watson Robert A, Tong Orion, Ye Weiyu, Nassiri Isar, Gilchrist James J, de Los Aires Alba Verge, Sharma Piyush Kumar, Koturan Surya, Cooper Rosalin A, Woodcock Victoria K, Jungkurth Elsita, Shine Brian, Coupe Nicholas, Payne Miranda J, Church David N, Naranbhai Vivek, Groha Stefan, Emery Paul, Mankia Kulveer, Freedman Matthew L, Choueiri Toni K, Middleton Mark R, Gusev Alexander, Fairfax Benjamin P

Abstract excerpt

Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7. We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) to IL7 in patients. Patients carrying the...

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Source

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Identifiers

PMID: 36526722
DOI: 10.1038/s41591-022-02095-5
PMCID: PMC9800275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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