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Article

Driver Mutation Subtypes Differentially Shape Immune Evasion Landscapes in Melanoma: An AI-Driven Inflammatory Pathway Model Implicating CCNE1.

Human mutation - 1 Jan 2026

Mao Chong, Chen Guobin, Tang Jiayu, Leng Rao, Zhou Xiyuan, Yang Jianing

Abstract excerpt

Background: Melanoma harbors highly heterogeneous tumor immune microenvironments shaped by driver mutations in BRAF, NRAS, and NF1. How mutational context modulates inflammatory signaling and immune evasion mechanisms of prognosis-related genes remains poorly understood. Methods: ssGSEA scored 15 inflammatory pathways across four cohorts (TCGA, GSE19234, GSE22153, and GSE65904). Cross-cohort univariate Cox...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42369209
DOI: 10.1155/humu/6776070
PMCID: PMC13309799

Genes

CCNE1
NF1
BRAF
NRAS
B2M
LAG3
TAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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