Article

Novel Anti-PD1 Predictive Signature and Functional Dendritic-Cell Biomarkers in Melanoma Identified with Systems Immunology

2025-07-08

Abstract excerpt

<title>Abstract</title> <p>Despite the success of anti-PD1 immunotherapy in melanoma, identifying biomarkers for response prediction and rational treatment combinations remains a major challenge. Effective dendritic cell (DC):CD8+ T cell crosstalk in the tumor microenvironment enhances anti-PD1 responses; however, no predictive signatures reflect this interaction. To address this, we developed a systems immunolog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e9014e3-5554-56bf-8d0a-c8f516396a4b
DOI: 10.21203/rs.3.rs-6680755/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel Anti-PD1 Predictive Signature and Functional Dendritic-Cell Biomarkers in Melanoma Identified with Systems ImmunologyDOI 10.21203/rs.3.rs-6680755/v1Read

A Novel Signature of 23 Immunity-related Gene Pairs is Prognostic of Cutaneous MelanomaSemantic proximity Read

The multi-omics landscape and clinical relevance of the immunological signature of phagocytosis regulators: Implications for risk classification and frontline therapies in skin cutaneous melanomaSemantic proximity Read

Integrative single-cell profiling of melanoma reveals a tumor microenvironment signature predictive of immunotherapy responseSemantic proximity Read

Construction of immune scores to predict patient prognosis and response of anti-PD1 treatment in stage III-IV melanomaSemantic proximity Read

Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockadeSemantic proximity Read

Development and Validation of An Immune-Related Gene Pair Signature in Skin Cutaneous MelanomaSemantic proximity Read

9-Gene Signature Correlated With CD8+ T Cell Infiltration Activated by IFN-γ: A Biomarker of Immune Checkpoint Therapy Response in MelanomaSemantic proximity Read

OMIC signatures to understand cancer immunosurveillance and immunoediting: Melanoma and immune cells interplay in immunotherapySemantic proximity Read

The expression pattern of immune-related genes and characterization of tumor immune microenvironment: predicting prognosis and immunotherapeutic effects in cutaneous melanomaSemantic proximity Read

Identifying biomarkers associated with immunotherapy response in melanoma by multi-omics analysisSemantic proximity Read

Immune Cell as a Promising Biomarker in the Diagnosis and Prognosis of Cutaneous Melanoma by Using Machine LearningSemantic proximity Read