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A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits

2026-08-26

Abstract excerpt

Non-coding regulatory variation drives complex traits, domestication, and evolutionary adaptation, yet the sheep genome lacks high-resolution functional annotation. Here we present SheepEpimap, a multi-tissue regulatory atlas harmonizing 516 CUT&Tag histone modifications, ATAC-seq, and RNA-seq datasets across 43 adult tissues in sheep. We annotated 2.93 million cis-regulatory elements, yielding 557,441 enhancer-ge...

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Literature Corpus work
36e72062-a290-52e1-b2ae-a45175d638f6
DOI
10.64898/2026.08.22.746371
Open publication

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A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traitsDOI 10.64898/2026.08.22.746371
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