Article

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma

2023-08-15

Abstract excerpt

<h4>Background</h4> Checkpoint blockade in cholangiocarcinoma (CCA) is promising; however, little is known about the response to treatment in CCA subtypes. In this study, we investigated the spatial immune environment in combination with checkpoint expression in perihilar CCA (pCCA). <h4>Materials & Methods</h4> The levels of checkpoint molecules (PD-1, PD-L1, PD-L2, LAG-3, ICOS, TIGIT, TIM-3, and CTLA-4), macro...

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Literature Corpus work: 36d65b5e-80ae-5602-bfee-21dee82d7ecd
DOI: 10.1101/2023.08.14.553195

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