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Article

Spatial immunophenotypes predict clinical outcome in intrahepatic cholangiocarcinoma

15 Apr 2023

Abstract excerpt

Background & Aims Intrahepatic cholangiocarcinoma (iCCA) is a severe malignant tumour that shows only modest responses to immunotherapy. We aimed to identify the spatial immunophenotypes of iCCA and delineate potential immune escape mechanisms. Method Multiplex immunohistochemistry (mIHC) was performed to quantitatively evaluate the distribution of 16 immune cell subsets in intratumour, invasive margin and...

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PMID: 37360908
DOI: 10.1016/j.jhepr.2023.100762

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