Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

Abstract excerpt

<h4>Background</h4> While there are medications that treat and manage age-related diseases, a compound that prolongs lifespan is yet to be discovered. Nonetheless, metformin, a commonly prescribed anti-diabetic medication, has repeatedly been shown to hinder aging in pre-clinical models and to be associated with lower mortality for humans, even among cancer patients. It is, however, not well understood how metfor...

Topics

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• Cancer, Hypoxia, and Metabolism
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Metabolism, Diabetes, and Cancer
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

36d1c3ab-a185-5fb3-9057-1dfe45fb6541

DOI

10.1101/2022.10.22.513357