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Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance

2 Aug 2023

Abstract excerpt

An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising that the epigenome also plays a crucial role in the pathogenesis of T2D. Hyperglycemia can indeed trigger epigenetic modifications, thereby regulating different gene expression patterns. Such epigenetic changes can persist after normalizing...

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PMID: 37541452
DOI: 10.1016/j.bcp.2023.115732

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