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Article

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

Molecular cell - 19 Apr 2018

Ordureau Alban, Paulo Joao A, Zhang Wei, Ahfeldt Tim, Zhang Jiuchun, Cohn Erin F, Hou Zhonggang, Heo Jin-Mi, Rubin Lee L, Sidhu Sachdev S, Gygi Steven P, Harper J Wade

Abstract excerpt

Flux through kinase and ubiquitin-driven signaling systems depends on the modification kinetics, stoichiometry, primary site specificity, and target abundance within the pathway, yet we rarely understand these parameters and their spatial organization within cells. Here we develop temporal digital snapshots of ubiquitin signaling on the mitochondrial outer membrane in embryonic stem cell-derived neurons, and we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29656925
DOI: 10.1016/j.molcel.2018.03.012
PMCID: PMC5910199

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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