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Article

PINK1 and Parkin: emerging themes in mitochondrial homeostasis

1 Apr 2017

Abstract excerpt

The Parkinson's disease (PD)-associated protein kinase, PTEN-induced putative kinase1 (PINK1), and ubiquitin E3 ligase Parkin, function in a common signalling pathway known to regulate mitochondrial network homeostasis and quality control, including mitophagy. The multistep activation of this pathway, as well as an unexpected convergence between the post-translational modifications of ubiquitylation and...

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Share to Autophagy in Disease and Therapy
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Identifiers

PMID: 28437683
DOI: 10.1016/j.ceb.2017.03.013

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