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Article

Notch3 signalling and vascular remodelling in pulmonary arterial hypertension

1 Dec 2019

Abstract excerpt

Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1-4) regulating diverse cellular processes have been identified. Of these, Notch3 is expressed almost exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the...

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PMID: 31868216
DOI: 10.1042/cs20190835

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