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Article

RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.

Molecular cancer research : MCR - 1 Jun 2013

Sun Daochun, Haddad Ramsi, Kraniak Janice M, Horne Steven D, Tainsky Michael A

Abstract excerpt

Malignant peripheral nerve sheath tumor (MPNST) is a type of soft tissue sarcoma that occurs in carriers of germline mutations in Nf1 gene as well as sporadically. Neurofibromin, encoded by the Nf1 gene, functions as a GTPase-activating protein (GAP) whose mutation leads to activation of wt-RAS and mitogen-activated protein kinase (MAPK) signaling in neurofibromatosis type I (NF1) patients' tumors. However,...

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Source

Identifiers

PMID: 23423222
DOI: 10.1158/1541-7786.MCR-12-0593

Genes

BMP2
NRAS
SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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