Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2013

Wik Elisabeth, Ræder Maria B, Krakstad Camilla, Trovik Jone, Birkeland Even, Hoivik Erling A, Mjos Siv, Werner Henrica M J, Mannelqvist Monica, Stefansson Ingunn M, Oyan Anne M, Kalland Karl H, Akslen Lars A, Salvesen Helga B

Abstract excerpt

PURPOSE: We hypothesized that estrogen receptor-α (ER-α) status in endometrial carcinomas, associated with poor prognosis, is reflected in transcriptional signatures suggesting targets for new therapy. EXPERIMENTAL DESIGN: Endometrial carcinoma samples in a primary investigation cohort (n = 76) a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Estrogen Receptor alpha

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Real-Time Polymerase Chain Reaction

Share to Survival Rate

Source

Identifiers

PMID: 23319822
DOI: 10.1158/1078-0432.CCR-12-3039

Genes

ESR1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23319822-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.PMID 23319822Read ↗

Estrogen receptor-alpha as a predictive biomarker in endometrioid endometrial cancer.Semantic proximity Read ↗

Estrogen Receptor, GATA-3, TTF-1, and KRAS in Endometrial Carcinoma of No Specific Molecular Profile: Prognostic or Diagnostic Markers?Semantic proximity Read ↗

Roles of estrogen receptor α in endometrial carcinoma (Review)Semantic proximity Read ↗

Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.Semantic proximity Read ↗

Rethinking the Estrogen Receptor Beta Dominance Hypothesis in Endometriosis: Insights from Single Cell RNA Sequencing Meta-analysisSemantic proximity Read ↗

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancerSemantic proximity Read ↗

ERα, microRNAs, and the epithelial–mesenchymal transition in breast cancerSemantic proximity Read ↗

Molecular profiling of estrogen receptor α and progesterone receptor transcript variants in endometrial cancer.Semantic proximity Read ↗

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancerSemantic proximity Read ↗

Genomic Function of Estrogen Receptor β in EndometriosisSemantic proximity Read ↗

A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT GenesSemantic proximity Read ↗

The estrogen receptor α cistrome in human endometrium and epithelial organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.