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Article

Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer

14 Jul 2017

Abstract excerpt

The limited clinical response to conventional chemotherapeutics observed in colorectal cancer (CRC) may be related to the connections between the hyperactivated β -catenin signaling and other pathways in CRC stem-like cells (CRC-SC). Here, we show the mechanistic link between the endothelin-1 (ET-1)/ET-1 receptor (ET-1R) signaling and β -catenin pathway through the specific interaction with the signal transducer...

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PMID: 28708138
DOI: 10.1038/cdd.2017.121

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