Article

Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis

2024-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Vγ9Vδ2T cells have the unique ability to recognize a broad range of malignant transformed cells. The tumor targeting event involving BTN2A1 and BTN3A1 dimers on the tumor cell surface is critical, leading to full activation of the TCR. Although the molecular mechanisms governing TCR engagement and T cell activation are well-characterized, the role of Vγ9Vδ2 T cells in cancer immune surveillance...

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Literature Corpus work: 369de96e-3a5c-5e26-ab54-3c96bda1c319
DOI: 10.1101/2024.11.19.624272

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