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Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors

17 Sept 2024

Abstract excerpt

BACKGROUNDNeoantigens derived from KRASMUT have been described, but the fine antigen specificity of T cell responses directed against these epitopes is poorly understood. Here, we explore KRASMUT immunogenicity and the properties of 4 T cell receptors (TCRs) specific for KRASG12V restricted to the HLA-A3 superfamily of class I alleles.METHODSA phase 1 clinical vaccine trial targeting KRASMUT was conducted. TCRs...

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PMID: 39287991
DOI: 10.1172/jci175790

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