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Article

DSG2-Directed CAR-T Cells Safely and Universally Eliminate Solid Tumors

2026-02-12

Abstract excerpt

<title>Abstract</title> <p>CAR-T cell therapies are curative for advanced hematologic cancers, however that potential has yet to be realized in epithelia-derived solid tumors reflecting the limited portfolio of cancer-restricted, cell-surface targets. Desmoglein 2 (DSG2) is a desmosomal cadherin universally overexpressed on the surface of transformed epithelial cells, with normal protein expression believed to be...

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Literature Corpus work
b2a13947-42f7-5d11-bfc4-bba48fb33b49
DOI
10.21203/rs.3.rs-5909002/v1
Open publication

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DSG2-Directed CAR-T Cells Safely and Universally Eliminate Solid TumorsDOI 10.21203/rs.3.rs-5909002/v1
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