Article

CRISPR-targeted display of functional T cell receptors enables engineering of enhanced specificity and prediction of cross-reactivity

2020-06-23

Abstract excerpt

<h4>ABSTRACT</h4> T cell receptor (TCR) gene therapy is a promising cell therapy approach for the treatment of cancer. However, most naturally occurring TCRs display low affinities to their peptide-MHC targets, and engineering of TCRs for enhanced affinity is complicated by the risk of introducing cross-reactivity and the poor correlation between affinity and function. Here we report the establishment of the TCR-...

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Literature Corpus work: 848ad761-f735-54f4-a855-986060649a3d
DOI: 10.1101/2020.06.23.166363

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