Article

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

2017-08-31

Abstract excerpt

Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK kinase cascade. Here we summarize the canonical role of KSR in cells, including its central role as a scaffold protei...

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Literature Corpus work: 369a55ab-8599-5b87-ae1b-bb535792438b
DOI: 10.12688/f1000research.11895.1

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