Article
RAS-mediated oncogenic signaling pathways in human malignancies.
Seminars in cancer biology - 1 Feb 2019
Khan Abdul Q, Kuttikrishnan Shilpa, Siveen Kodappully S, Prabhu Kirti S, Shanmugakonar Muralitharan, Al-Naemi Hamda A, Haris Mohammad, Dermime Said, Uddin Shahab
Abstract excerpt
Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its regulators, most frequent in human cancers, are the main force for incessant RAS activation and associated pathological conditions including cancer. In general, RAS is the main upstream regulator...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.