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Article

<i>In vivo</i> silencing of regulatory elements using a single AAV-CRISPRi vector

2023-11-06

Abstract excerpt

CRISPR-Cas9 based transcriptional repressors (CRISPRi) have emerged as specific and robust tools for functional epigenetic silencing of regulatory elements. Adeno-associated viruses (AAVs) are promising CRISPRi delivery vectors for cardiovascular research and therapy. However, compact vectors enabling codelivery of all CRISPRi components by a single AAV are needed for an enhanced and consistent performance. We eng...

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Identifiers and source

Literature Corpus work
368f0640-01a6-5a68-a692-35fc61d17429
DOI
10.1101/2023.11.05.565512
Open publication

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<i>In vivo</i> silencing of regulatory elements using a single AAV-CRISPRi vectorDOI 10.1101/2023.11.05.565512
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