NMR studies of interactions of ligands with dihydrofolate reductase.

doi:10.1016/0006-2952(90)90189-r

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Article

NMR studies of interactions of ligands with dihydrofolate reductase.

Biochemical pharmacology - 1 Jul 1990

Feeney J

Abstract excerpt

NMR spectroscopy is a useful technique for studying interactions, conformations and dynamic processes within ligand-protein complexes. Several examples of the application of the method to studies of complexes of anti-folate drugs with their target enzyme, dihydrofolate reductase, are discussed.

Topics

Drug Interactions
Ligands
Magnetic Resonance Spectroscopy
Methotrexate
Molecular Conformation
Mutation
Tetrahydrofolate Dehydrogenase
Trimethoprim

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