Article

Pharmacological Restoration of Mitochondrial Permeability Transition Pore Flickering by High-Content Drug Repurposing

2026-01-26

Abstract excerpt

The mitochondrial permeability transition pore (mPTP) is a voltage- and calcium-regulated channel located in the inner mitochondrial membrane whose activity critically influences cellular fate. While prolonged pore opening leads to mitochondrial depolarization, matrix swelling, and cell death, brief and reversible opening events, referred to as flickering, enable controlled release of calcium and reactive oxygen s...

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Literature Corpus work: 3685916b-3de7-516c-9316-dbd30dc0899d
DOI: 10.64898/2026.01.23.701330

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