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Article

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Biochimica et biophysica acta - 1 Feb 2015

Leonard Anthony P, Cameron Robert B, Speiser Jaime L, Wolf Bethany J, Peterson Yuri K, Schnellmann Rick G, Beeson Craig C, Rohrer Bärbel

Abstract excerpt

Understanding the processes of mitochondrial dynamics (fission, fusion, biogenesis, and mitophagy) has been hampered by the lack of automated, deterministic methods to measure mitochondrial morphology from microscopic images. A method to quantify mitochondrial morphology and function is presented here using a commercially available automated high-content wide-field fluorescent microscopy platform and R...

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Identifiers

PMID: 25447550
DOI: 10.1016/j.bbamcr.2014.11.002
PMCID: PMC4289477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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