Article

Protective effect of dihydropteridine reductase against oxidative stress is abolished with A278C mutation*

2017-09-01

Abstract excerpt

Objective: To evaluate the antioxidation of dihydrobiopterin reductase and to explore the effect of A278C mutation of the quinoid dihydropteridine reductase (QDPR) gene on its antioxidant activity. Methods: First, plasmids with different genes (wild and mutant QDPR) were constructed. After gene sequencing, they were transfected into human kidney cells (HEK293T). Then, the intracellular production of reactive oxyge...

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Identifiers and source

Literature Corpus work: 367da0fb-3c0b-5eb5-a726-aa5364800f11
DOI: 10.1631/jzus.b1600123
PMCID: PMC5611548

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