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Article

Effect of genetic variation on human cytochrome p450 reductase-mediated paraquat cytotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2006

Han Jing-Fen, Wang Shou-Lin, He Xiao-Yang, Liu Chun-Yong, Hong Jun-Yan

Abstract excerpt

Paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride) is a widely used herbicide and is highly toxic to human and animals. The mechanisms of paraquat toxicity involve the generation of superoxide anion through the process of redox cycling. NADPH-cytochrome P450 oxidoreductase (POR) has been reported to be a major enzyme for one-electron reduction of paraquat that initiates the redox cycling. Recently, a total of...

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PMID: 16495354
DOI: 10.1093/toxsci/kfj139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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