Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative Stress

1 Feb 2009

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) has been implicated in the regulation of cellular antioxidative mechanisms. Tumor cells often lose the balance of oxidation and antioxidation, but the role of G6PD in such an imbalance is still largely unknown. To investigate the related function of G6PD in tumor cells, we established a stable line of A375 human melanoma cells with G6PD gene knockdown by a shRNA lentiviral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia and Neurotoxicity Research
Share to Cancer, Hypoxia, and Metabolism
Share to Neonatal Health and Biochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19243250
DOI: 10.1089/cbr.2008.0494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative StressPMID 19243250Read ↗

Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model.Semantic proximity Read ↗

Glucose-6-phosphate Dehydrogenase: a Biomarker and Potential Therapeutic Target for CancerSemantic proximity Read ↗

Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review).Semantic proximity Read ↗

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysisSemantic proximity Read ↗

The Redox Role of G6PD in Cell Growth, Cell Death, and CancerSemantic proximity Read ↗

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancerSemantic proximity Read ↗

G6PD protects from oxidative damage and improves healthspan in miceSemantic proximity Read ↗

Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude miceSemantic proximity Read ↗

DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cellsSemantic proximity Read ↗

Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells.Semantic proximity Read ↗

Development of a novel mouse model of severe glucose-6-phosphate dehydrogenase (G6PD)-deficiency for in vitro and in vivo assessment of hemolytic toxicity to red blood cells.Semantic proximity Read ↗

Photodynamic Therapy Using Talaporfin Sodium and Semiconductor Laser Induces Dose and Time Dependent Cytocidal Effect for Human Glioma Derived Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.